Sideroxylin (Callistemon lanceolatus) suppressed cell proliferation and increased apoptosis in ovarian cancer cells accompanied by mitochondrial dysfunction, the generation of reactive oxygen species, and an increase of lipid peroxidation.
Identifieur interne : 000183 ( Main/Exploration ); précédent : 000182; suivant : 000184Sideroxylin (Callistemon lanceolatus) suppressed cell proliferation and increased apoptosis in ovarian cancer cells accompanied by mitochondrial dysfunction, the generation of reactive oxygen species, and an increase of lipid peroxidation.
Auteurs : Sunwoo Park [Corée du Sud] ; Whasun Lim [Corée du Sud] ; Wonsik Jeong [Corée du Sud] ; Fuller W. Bazer [États-Unis] ; Dongho Lee [Corée du Sud] ; Gwonhwa Song [Corée du Sud]Source :
- Journal of cellular physiology [ 1097-4652 ] ; 2018.
Descripteurs français
- KwdFr :
- Apoptose (effets des médicaments et des substances chimiques), Espèces réactives de l'oxygène (métabolisme), Femelle (MeSH), Flavonoïdes (composition chimique), Flavonoïdes (pharmacologie), Humains (MeSH), Lignée cellulaire tumorale (MeSH), Mitochondries (anatomopathologie), Mitochondries (effets des médicaments et des substances chimiques), Myrtaceae (composition chimique), Peroxydation lipidique (effets des médicaments et des substances chimiques), Phosphorylation (effets des médicaments et des substances chimiques), Prolifération cellulaire (effets des médicaments et des substances chimiques), Stress oxydatif (effets des médicaments et des substances chimiques), Système de signalisation des MAP kinases (effets des médicaments et des substances chimiques), Tumeurs de l'ovaire (anatomopathologie), Tumeurs de l'ovaire (génétique), Tumeurs de l'ovaire (traitement médicamenteux).
- MESH :
- anatomopathologie : Mitochondries, Tumeurs de l'ovaire.
- composition chimique : Flavonoïdes, Myrtaceae.
- effets des médicaments et des substances chimiques : Apoptose, Mitochondries, Peroxydation lipidique, Phosphorylation, Prolifération cellulaire, Stress oxydatif, Système de signalisation des MAP kinases.
- génétique : Tumeurs de l'ovaire.
- métabolisme : Espèces réactives de l'oxygène.
- pharmacologie : Flavonoïdes.
- traitement médicamenteux : Tumeurs de l'ovaire.
- Femelle, Humains, Lignée cellulaire tumorale.
English descriptors
- KwdEn :
- Apoptosis (drug effects), Cell Line, Tumor (MeSH), Cell Proliferation (drug effects), Female (MeSH), Flavonoids (chemistry), Flavonoids (pharmacology), Humans (MeSH), Lipid Peroxidation (drug effects), MAP Kinase Signaling System (drug effects), Mitochondria (drug effects), Mitochondria (pathology), Myrtaceae (chemistry), Ovarian Neoplasms (drug therapy), Ovarian Neoplasms (genetics), Ovarian Neoplasms (pathology), Oxidative Stress (drug effects), Phosphorylation (drug effects), Reactive Oxygen Species (metabolism).
- MESH :
- chemical , chemistry : Flavonoids.
- chemistry : Myrtaceae.
- drug effects : Apoptosis, Cell Proliferation, Lipid Peroxidation, MAP Kinase Signaling System, Mitochondria, Oxidative Stress, Phosphorylation.
- drug therapy : Ovarian Neoplasms.
- genetics : Ovarian Neoplasms.
- chemical , metabolism : Reactive Oxygen Species.
- pathology : Mitochondria, Ovarian Neoplasms.
- chemical , pharmacology : Flavonoids.
- Cell Line, Tumor, Female, Humans.
Abstract
Sideroxylin is a C-methylated flavone isolated from Callistemon lanceolatus and exerts antimicrobial activity against Staphylococcus aureus. However, the anticancer effects of sideroxylin and its intracellular signaling mechanisms have not yet been identified. Results of our study showed that sideroxylin decreased cell proliferation and increased apoptosis, causing DNA fragmentation, depolarization of the mitochondrial membrane, the generation of reactive oxygen species, and an increase of lipid peroxidation in ovarian cancer cells (ES2 and OV90 cells). Additionally, sideroxylin activated the phosphorylation of ERK1/2, JNK, P38, and MAPK proteins and the use of LY294002, U0126, SB203580, and SP600125 to block their phosphorylation, respectively, in ES2 and OV90 cells. Collectively, the results of present study indicated that sideroxylin was a novel therapeutic agent to combat the proliferation of ovarian cancer cells through the induction of mitochondrial dysfunction and the activation of PI3 K and MAPK signal transduction.
DOI: 10.1002/jcp.26540
PubMed: 29904922
Affiliations:
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Bazer</name><affiliation wicri:level="2"><nlm:affiliation>Center for Animal Biotechnology and Genomics and Department of Animal Science, Texas A&M University, College Station, Texas.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Center for Animal Biotechnology and Genomics and Department of Animal Science, Texas A&M University, College Station</wicri:cityArea></affiliation></author><author><name sortKey="Lee, Dongho" sort="Lee, Dongho" uniqKey="Lee D" first="Dongho" last="Lee">Dongho Lee</name><affiliation wicri:level="3"><nlm:affiliation>Department of Biosystems and Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Biosystems and Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Song, Gwonhwa" sort="Song, Gwonhwa" uniqKey="Song G" first="Gwonhwa" last="Song">Gwonhwa Song</name><affiliation wicri:level="3"><nlm:affiliation>Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author></analytic><series><title level="j">Journal of cellular physiology</title><idno type="eISSN">1097-4652</idno><imprint><date when="2018" type="published">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Apoptosis (drug effects)</term><term>Cell Line, Tumor (MeSH)</term><term>Cell Proliferation (drug effects)</term><term>Female (MeSH)</term><term>Flavonoids (chemistry)</term><term>Flavonoids (pharmacology)</term><term>Humans (MeSH)</term><term>Lipid Peroxidation (drug effects)</term><term>MAP Kinase Signaling System (drug effects)</term><term>Mitochondria (drug effects)</term><term>Mitochondria (pathology)</term><term>Myrtaceae (chemistry)</term><term>Ovarian Neoplasms (drug therapy)</term><term>Ovarian Neoplasms (genetics)</term><term>Ovarian Neoplasms (pathology)</term><term>Oxidative Stress (drug effects)</term><term>Phosphorylation (drug effects)</term><term>Reactive Oxygen Species (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Apoptose (effets des médicaments et des substances chimiques)</term><term>Espèces réactives de l'oxygène (métabolisme)</term><term>Femelle (MeSH)</term><term>Flavonoïdes (composition chimique)</term><term>Flavonoïdes (pharmacologie)</term><term>Humains (MeSH)</term><term>Lignée cellulaire tumorale (MeSH)</term><term>Mitochondries (anatomopathologie)</term><term>Mitochondries (effets des médicaments et des substances chimiques)</term><term>Myrtaceae (composition chimique)</term><term>Peroxydation lipidique (effets des médicaments et des substances chimiques)</term><term>Phosphorylation (effets des médicaments et des substances chimiques)</term><term>Prolifération cellulaire (effets des médicaments et des substances chimiques)</term><term>Stress oxydatif (effets des médicaments et des substances chimiques)</term><term>Système de signalisation des MAP kinases (effets des médicaments et des substances chimiques)</term><term>Tumeurs de l'ovaire (anatomopathologie)</term><term>Tumeurs de l'ovaire (génétique)</term><term>Tumeurs de l'ovaire (traitement médicamenteux)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Flavonoids</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Mitochondries</term><term>Tumeurs de l'ovaire</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Myrtaceae</term></keywords><keywords scheme="MESH" qualifier="composition chimique" xml:lang="fr"><term>Flavonoïdes</term><term>Myrtaceae</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Apoptosis</term><term>Cell Proliferation</term><term>Lipid Peroxidation</term><term>MAP Kinase Signaling System</term><term>Mitochondria</term><term>Oxidative Stress</term><term>Phosphorylation</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Ovarian Neoplasms</term></keywords><keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Apoptose</term><term>Mitochondries</term><term>Peroxydation lipidique</term><term>Phosphorylation</term><term>Prolifération cellulaire</term><term>Stress oxydatif</term><term>Système de signalisation des MAP kinases</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Ovarian Neoplasms</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Tumeurs de l'ovaire</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Reactive Oxygen Species</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Espèces réactives de l'oxygène</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Mitochondria</term><term>Ovarian Neoplasms</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Flavonoïdes</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Flavonoids</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Tumeurs de l'ovaire</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Cell Line, Tumor</term><term>Female</term><term>Humans</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Femelle</term><term>Humains</term><term>Lignée cellulaire tumorale</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Sideroxylin is a C-methylated flavone isolated from Callistemon lanceolatus and exerts antimicrobial activity against Staphylococcus aureus. However, the anticancer effects of sideroxylin and its intracellular signaling mechanisms have not yet been identified. Results of our study showed that sideroxylin decreased cell proliferation and increased apoptosis, causing DNA fragmentation, depolarization of the mitochondrial membrane, the generation of reactive oxygen species, and an increase of lipid peroxidation in ovarian cancer cells (ES2 and OV90 cells). Additionally, sideroxylin activated the phosphorylation of ERK1/2, JNK, P38, and MAPK proteins and the use of LY294002, U0126, SB203580, and SP600125 to block their phosphorylation, respectively, in ES2 and OV90 cells. Collectively, the results of present study indicated that sideroxylin was a novel therapeutic agent to combat the proliferation of ovarian cancer cells through the induction of mitochondrial dysfunction and the activation of PI3 K and MAPK signal transduction.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">29904922</PMID><DateCompleted><Year>2019</Year><Month>09</Month><Day>25</Day></DateCompleted><DateRevised><Year>2019</Year><Month>09</Month><Day>25</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1097-4652</ISSN><JournalIssue CitedMedium="Internet"><Volume>233</Volume><Issue>11</Issue><PubDate><Year>2018</Year><Month>11</Month></PubDate></JournalIssue><Title>Journal of cellular physiology</Title><ISOAbbreviation>J Cell Physiol</ISOAbbreviation></Journal><ArticleTitle>Sideroxylin (Callistemon lanceolatus) suppressed cell proliferation and increased apoptosis in ovarian cancer cells accompanied by mitochondrial dysfunction, the generation of reactive oxygen species, and an increase of lipid peroxidation.</ArticleTitle><Pagination><MedlinePgn>8597-8604</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/jcp.26540</ELocationID><Abstract><AbstractText>Sideroxylin is a C-methylated flavone isolated from Callistemon lanceolatus and exerts antimicrobial activity against Staphylococcus aureus. However, the anticancer effects of sideroxylin and its intracellular signaling mechanisms have not yet been identified. Results of our study showed that sideroxylin decreased cell proliferation and increased apoptosis, causing DNA fragmentation, depolarization of the mitochondrial membrane, the generation of reactive oxygen species, and an increase of lipid peroxidation in ovarian cancer cells (ES2 and OV90 cells). Additionally, sideroxylin activated the phosphorylation of ERK1/2, JNK, P38, and MAPK proteins and the use of LY294002, U0126, SB203580, and SP600125 to block their phosphorylation, respectively, in ES2 and OV90 cells. Collectively, the results of present study indicated that sideroxylin was a novel therapeutic agent to combat the proliferation of ovarian cancer cells through the induction of mitochondrial dysfunction and the activation of PI3 K and MAPK signal transduction.</AbstractText><CopyrightInformation>© 2018 Wiley Periodicals, Inc.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Park</LastName><ForeName>Sunwoo</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul, Republic of Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lim</LastName><ForeName>Whasun</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>Department of Biomedical Sciences, Catholic Kwandong University, Gangneung, Republic of Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jeong</LastName><ForeName>Wonsik</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>Bio-Center, Gyeonggido Business and Science Accelerator, Suwon, Republic of Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bazer</LastName><ForeName>Fuller W</ForeName><Initials>FW</Initials><AffiliationInfo><Affiliation>Center for Animal Biotechnology and Genomics and Department of Animal Science, Texas A&M University, College Station, Texas.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lee</LastName><ForeName>Dongho</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Biosystems and Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul, Republic of Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Song</LastName><ForeName>Gwonhwa</ForeName><Initials>G</Initials><Identifier Source="ORCID">0000-0003-2817-5323</Identifier><AffiliationInfo><Affiliation>Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul, Republic of Korea.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2018</Year><Month>06</Month><Day>15</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Cell Physiol</MedlineTA><NlmUniqueID>0050222</NlmUniqueID><ISSNLinking>0021-9541</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D005419">Flavonoids</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D017382">Reactive Oxygen Species</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C561549">sideroxylin</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D017209" MajorTopicYN="N">Apoptosis</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D045744" MajorTopicYN="N">Cell Line, Tumor</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D049109" MajorTopicYN="N">Cell Proliferation</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005419" MajorTopicYN="N">Flavonoids</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015227" MajorTopicYN="N">Lipid Peroxidation</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D020935" MajorTopicYN="N">MAP Kinase Signaling System</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008928" MajorTopicYN="N">Mitochondria</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D027822" MajorTopicYN="N">Myrtaceae</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010051" MajorTopicYN="N">Ovarian Neoplasms</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018384" MajorTopicYN="N">Oxidative Stress</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010766" MajorTopicYN="N">Phosphorylation</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017382" MajorTopicYN="N">Reactive Oxygen Species</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">Callistemon lanceolatus</Keyword><Keyword MajorTopicYN="Y">apoptosis</Keyword><Keyword MajorTopicYN="Y">ovarian cancer</Keyword><Keyword MajorTopicYN="Y">sideroxylin</Keyword><Keyword MajorTopicYN="Y">signal transduction</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2018</Year><Month>01</Month><Day>15</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2018</Year><Month>02</Month><Day>12</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2018</Year><Month>6</Month><Day>16</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2019</Year><Month>9</Month><Day>26</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2018</Year><Month>6</Month><Day>16</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">29904922</ArticleId><ArticleId IdType="doi">10.1002/jcp.26540</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Corée du Sud</li><li>États-Unis</li></country><region><li>Région capitale de Séoul</li><li>Texas</li></region><settlement><li>Séoul</li></settlement></list><tree><country name="Corée du Sud"><region name="Région capitale de Séoul"><name sortKey="Park, Sunwoo" sort="Park, Sunwoo" uniqKey="Park S" first="Sunwoo" last="Park">Sunwoo Park</name></region><name sortKey="Jeong, Wonsik" sort="Jeong, Wonsik" uniqKey="Jeong W" first="Wonsik" last="Jeong">Wonsik Jeong</name><name sortKey="Lee, Dongho" sort="Lee, Dongho" uniqKey="Lee D" first="Dongho" last="Lee">Dongho Lee</name><name sortKey="Lim, Whasun" sort="Lim, Whasun" uniqKey="Lim W" first="Whasun" last="Lim">Whasun Lim</name><name sortKey="Song, Gwonhwa" sort="Song, Gwonhwa" uniqKey="Song G" first="Gwonhwa" last="Song">Gwonhwa Song</name></country><country name="États-Unis"><region name="Texas"><name sortKey="Bazer, Fuller W" sort="Bazer, Fuller W" uniqKey="Bazer F" first="Fuller W" last="Bazer">Fuller W. 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}}
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HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:29904922" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a MitoPlantRedoxV1
| This area was generated with Dilib version V0.6.38. |  |